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AASM - Asian -African Society of Mycobacteriology

Researchers created genetic blueprint of TB bacteria, then used it to predict, rank potential drug targets

Home » News » Researchers created genetic blueprint of TB bacteria, then used it to predict, rank potential drug targets

Researchers have deciphered how the human pathogen Mycobacterium tuberculosis is able to tolerate the recently approved FDA drug bedaquiline. The rise in multi-drug resistant (MDR) and extremely drug resistant (XDR) strains of Mycobacterium tuberculosis (MTB) is becoming a major cause of global health concern for treating tuberculosis, which affects a third of the global population. In fact, the number of worldwide deaths caused by tuberculosis has surpassed HIV/AIDS, and there is greater sense of urgency than ever before to find effective drug cocktails to outsmart MTB. In a landmark study, researchers demonstrated a systems biology approach that has the potential to rationally predict combinations of drugs that will disrupt tolerance networks in MTB, making it even most susceptible to antibiotic therapy.

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