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AASM - Asian -African Society of Mycobacteriology

Fixed-dose combinations vs. single-drug for treating pulmonary TB

Home » News » Fixed-dose combinations vs. single-drug for treating pulmonary TB

A research team from Spain has prepared a Cochrane Systematic Review that explores the efficacy, safety, and adherence to fixed-dose combinations (FDCs) of drugs versus single-drug formulations to treat people who are newly diagnosed with tuberculosis (TB).The Cochrane review found there is probably little or no difference between FDCs compared to single-drug formulations for treatment failure. However, relapse may be more frequent following treatment with FDCs, and the number of deaths were similar between the two groups. Furthermore, the review showed little or no difference in serious adverse effects or events that led to discontinuation of therapy between the two regimes. Regarding TB diagnosis, there was little or no difference in sputum smear or culture conversion.

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